Nystatin Functional Medicine Protocol for SIFO
Antifungal Phase (kill phase)Nystatin:
Standard: 500,000 IU — 1 tablet/capsule 3–4× daily with meals
Stubborn cases: 1,000,000 IU — 3× daily
Herbal antifungal rotation (to reduce resistance):
Caprylic acid, oregano oil, berberine, or undecylenic acid
Rotate every 7–10 days
Duration: 3–6 weeks
Dietary Phase (starve the yeast)Remove: sugars, refined carbs, alcohol, fermented foods (if reactive)
Base diet: non-starchy vegetables, clean proteins, healthy fats
Low FODMAP or Specific Carbohydrate Diet (SCD) may help if SIBO is also present
Support Phase (detox & gut healing)Binders: activated charcoal, bentonite clay, chlorella — take 1–2 hours away from meds/supplements to mop up yeast toxins
Liver support: milk thistle, NAC, dandelion root tea
Hydration: 2–3 L water daily to flush die-off toxins
Rebuild Phase (after antifungal course)Probiotics:
Start with soil-based probiotics (e.g., Bacillus species)
Add Lactobacillus/Bifidobacterium blends after 1–2 weeks
Prebiotics (only if tolerated): partially hydrolyzed guar gum, acacia fiber
Gut lining repair: L-glutamine, zinc carnosine, aloe vera
Maintenance PhaseKeep sugars low for at least 2–3 months after treatment
Continue probiotics daily
Repeat a short herbal antifungal cycle every few months if prone to relapse
